Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells

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Sep 7, 2008 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Sep 7, 2008; 14(33): 5162-5175
Published online Sep 7, 2008. doi: 10.3748/wjg.14.5162

Table 6 Analysis of the combined effects of doxorubicin and Rosco on human colorectal cancer cell lines

Combined treatment of doxorubicin and Rosco	Combination interaction at various durations of treatment in human colorectal cancer cells¹
Combined treatment of doxorubicin and Rosco	SW48			SW1116			SW837
	2 d	4 d	6 d	2 d	4 d	6 d	2 d	4 d	6 d
Dox 0.5 IC₅₀ + Rosco 1.0 μg/mL	ant	ant	ant	syn	syn	syn	syn	syn	syn
Dox 1.0 IC₅₀ + Rosco 10 μg/mL	ant	ant	ant	syn	syn	syn	syn	syn	syn
Dox 2.0 IC₅₀ + Rosco 15 μg/mL	ant	ant	ant	syn	syn	syn	syn	syn	syn
Dox 3.0 IC₅₀ + Rosco 20 μg/mL	ant	add	add	syn	syn	add	syn	syn	add
Dox 4.0 IC₅₀ + Rosco 25 μg/mL	ant	add	add	syn	ant	add	syn	ant	ant

¹The data are based on the mean of absorbance measurements of 3 independent experiments; ant: Antagonistic; add: Additive; syn: Synergistic.

Citation: Abaza MSI, Bahman AMA, Al-Attiyah RJ. Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells. World J Gastroenterol 2008; 14(33): 5162-5175
URL: https://www.wjgnet.com/1007-9327/full/v14/i33/5162.htm
DOI: https://dx.doi.org/10.3748/wjg.14.5162