Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells

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Sep 7, 2008 (publication date) through Apr 19, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Colorectal Cancer

World J Gastroenterol. Sep 7, 2008; 14(33): 5162-5175
Published online Sep 7, 2008. doi: 10.3748/wjg.14.5162

Table 4 Analysis of the combined effects of 5-FU and Rosco on human colorectal cancer cell lines

Combined treatment of 5-FU and Rosco	Combination interaction at various durations of treatment in human colorectal cancer cells¹
Combined treatment of 5-FU and Rosco	SW48			SW1116			SW837
	2 d	4 d	6 d	2 d	4 d	6 d	2 d	4 d	6 d
5-FU 0.5 IC₅₀ + Rosco 1.0 μg/mL	ant	ant	ant	syn	syn	syn	ant	ant	add
5-FU 1.0 IC₅₀ + Rosco 15 μg/mL	ant	ant	ant	syn	syn	syn	ant	syn	add
5-FU 2.0 IC₅₀ + Rosco 20 μg/mL	ant	ant	ant	syn	add	add	add	ant	ant
5-FU 3.0 IC₅₀ + Rosco 25 μg/mL	ant	ant	add	ant	ant	ant	add	ant	ant

¹The data are based on the mean of absorbance measurements of 3 independent experiments; ant: Antagonistic; add: Additive; syn: Synergistic.

Citation: Abaza MSI, Bahman AMA, Al-Attiyah RJ. Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells. World J Gastroenterol 2008; 14(33): 5162-5175
URL: https://www.wjgnet.com/1007-9327/full/v14/i33/5162.htm
DOI: https://dx.doi.org/10.3748/wjg.14.5162