Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells

Table 3 IC₅₀ and sensitization ratio of 5-FU and its combinations with Rosco towards human colorectal cancer cell lines

Treatment with 5-FU and combinations with Rosco	IC50 (mol/L)			Sensitization ratio1
	SW48	SW1116	SW837	SW48	SW1116	SW837
5-FU	4.8 × 10-5	2.5 × 10-5	4.8 × 10-5	-	-	-
5-FU + 5 μg/mL Rosco	5.7 × 10-9	6.7 × 10-6	1.8 × 10-6	8.42 × 103	3.73	26.7
5-FU + 10 μg/mL Rosco	5.7 × 10-9	1.0 × 10-7	9.1 × 10-9	8.42 × 103	250	5.28 × 103

¹Sensitization ratio = IC₅₀ (5-FU)/IC₅₀ (5-FU + Rosco).