Revaluation of clinical and histological criteria for diagnosis of dysmetabolic iron overload syndrome

Table 4 Iron indices in patients according to the presence of ≥ 2 components of MS or steatosis

	Number of MS components			Hepatic steatosis
	0-1 (n = 34)	P	≥2 (n = 47)	Absent (n = 34)	P	Present (n = 47)
Transferrin saturation (%)	44 (28-118)	0.0058	36 (21-99)	39 (23-118)	> 0.05	39 (21-76)
Total Iron Score	24 (12-46)	0.0008	17 (12-39)	24.5 (12-46)	< 0.0001	16 (12-39)
HHII	0.51 (0.3-1.21)	< 0.0001	0.33 (0.2-0.57)	0.43 (0.23-1.1)	0.0004	0.34 (0.19-1.2)
SIS/TIS	0.21 (0.1-0.5)	0.0185	0.25 (0.11-0.4)	0.22 (0.1-0.5)	0.032	0.25 (0.09-0.4)
MS components ≥ 2	-		-	11 (32)	< 0.0001	36 (77)
Degree of hepatic steatosis (%)	0 (0-80)	< 0.0001	40 (0-98)	-		-

Data are reported as median (range) or number (%). HHII: Histological hepatic iron index (ratio of TIS to age); SIS/TIS: Sinusoidal/total iron score. Hepatic steatosis, absent when ≤ 5% of hepatocytes are involved; present when at least 5% of hepatocytes are involved.