©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jan 21, 2008; 14(3): 331-337
Published online Jan 21, 2008. doi: 10.3748/wjg.14.331
Published online Jan 21, 2008. doi: 10.3748/wjg.14.331
Table 4 Evidence for the influence of immune mechanisms on the aetiology of PSC
| Humoral immunity | Increased circulating immune complexes |
| Elevated immunoglobulin levels (IgG and IgM) | |
| Low titres of non-organ specific autoantibodies (ANA and SMA) | |
| High titres of antineutrophil antibodies | |
| Autoantibodies to BEC surface antigens | |
| Cell mediated immunity | Decreased levels of circulating peripheral CD8+ve Tcells |
| Portal T cell and NK cell infiltrate | |
| Increased activated and memory T cells | |
| Restricted T cell receptor repertoire (Vβ3) | |
| Aberrant expression of HLA-DR on BEC | |
| Coexpression of costimulatory molecules and HLA-DR on BECs | |
| Increased circulating and tissue bound adhesion molecules | |
| Immune effector mechanisms | Enhanced cytokine expression in the liver |
| Immunogenetic mechanisms | HLA associations |
- Citation: Saich R, Chapman R. Primary sclerosing cholangitis, autoimmune hepatitis and overlap syndromes in inflammatory bowel disease. World J Gastroenterol 2008; 14(3): 331-337
- URL: https://www.wjgnet.com/1007-9327/full/v14/i3/331.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.331