Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy

Table 6 Genotype and allele frequencies of ATG16L1 and IL23R SNPs in UC cases stratified by phenotypic subgroups, (n)

SNP/gene genotype	rs2241880 ATG16L1					rs7517847 IL23R					rs11209026 IL23R
	AA (141)	AG (315)	GG (212)	Total (668)	Freq (G) 0.553	GG (88)	GT (390)	TT (326)	Total (804)	Freq (G) 0.352	AA (1)	AG (72)	GG (750)	Total (823)	Freq (A) 0.045
Sex
Male	77	183	112	372	0.547	41	236	185	462	0.344	0	45	432	477	0.047
Female	64	132	100	296	0.561	47	154	141	342	0.363	1	27	318	346	0.042
Age at diagnosis (yr)
≤ 16 (A1)	30	58	48	136	0.566	15	76	49	140	0.379	0	11	129	140	0.039
17-40 (A2)	79	159	102	340	0.534	40	213	170	423	0.346	0	33	401	434	0.038
> 40 (A3)	24	84	55	163	0.595	28	86	89	203	0.350	1	25	184	210	0.064
Disease localization
Rectum	18	41	15	74	0.480	13	38	39	90	0.356	1	8	80	89	0.056
Rectum-sigmoid	20	55	39	114	0.583	20	82	46	148	0.412	0	21	134	155	0.068
Left colon	41	101	64	206	0.556	27	104	100	231	0.342	0	19	215	234	0.041
Colon	54	104	86	244	0.566	24	148	124	296	0.331	0	22	283	305	0.036
Perianal disease
Yes	3	3	6	12	0.625	0	6	8	14	0.214	0	2	13	15	0.067
No	129	298	198	625	0.555	82	367	301	750	0.354	1	67	699	767	0.045
Smoking history
No	81	173	125	379	0.558	51	203	185	439	0.347	1	38	408	447	0.045
Yes	25	54	25	104	0.500	10	65	41	116	0.366	0	12	104	116	0.052
Ex	25	72	51	148	0.588	20	105	77	202	0.359	0	18	191	209	0.043
Surgery
Yes	11	33	26	70	0.607	9	37	35	81	0.340	0	9	74	83	0.054
No	122	268	178	568	0.549	74	337	274	685	0.354	1	61	638	700	0.045

Only patients with at least 2 years of follow-up from diagnosis were included.