Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: Role of serine protease inhibitor Kazal 1type and alcohol

doi:10.3748/wjg.14.4486

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 28, 2008; 14(28): 4486-4491
Published online Jul 28, 2008. doi: 10.3748/wjg.14.4486

Table 4 CASR genotype comparison for R990G polymorphism in CP patients and controls with similar alcohol drinking patterns

	Patients	Controls	P¹	OR (95% CI)
A/L Alcohol CP patients vs controls (%)
AA	69 (83)	136 (88)
AG	13 (16)	18 (11)
GG	1 (1)	1 (1)
AA vs AG/GG			0.332	1.45 (0.69-3.07)
M/H Alcohol CP patients vs controls (%)
AA	59 (81)	106 (93)
AG	14 (19)	8 (7)
GG	0	0
AA vs AG/GG			0.018	3.12 (1.14-9.13)
VH Alcohol CP patients vs controls (%)
AA	37 (84)	21 (91)
AG	7 (16)	2 (9)
GG	0	0
AA vs AG/GG			0.708	1.99 (0.38-0.45)

A: Abstainer; L: Light; M: Moderate; H: Heavy; VH: Very heavy. Alcohol categories: Abstainers: No alcohol use or < 20 drinks in lifetime; Light drinkers: < 3 drinks/week; Moderate drinkers: 4-7 drinks/week for females, 4-14 drinks/week for males; Heavy drinkers: 8-34 drinks/week for females, 15-34 drinks/week for males; Very heavy drinkers: > 35 drinks/week.

¹Fisher’s exact test.

Citation: Muddana V, Lamb J, Greer JB, Elinoff B, Hawes RH, Cotton PB, Anderson MA, Brand RE, Slivka A, Whitcomb DC. Association between calcium sensing receptor gene polymorphisms and chronic pancreatitis in a US population: Role of serine protease inhibitor Kazal 1type and alcohol. World J Gastroenterol 2008; 14(28): 4486-4491
URL: https://www.wjgnet.com/1007-9327/full/v14/i28/4486.htm
DOI: https://dx.doi.org/10.3748/wjg.14.4486