Orthotopic liver transplantation as a rescue operation for recurrent hepatocellular carcinoma after partial hepatectomy

Table 3 Univariable Cox proportional hazards models

	Factor	Hazard ratio (95% CI)	P
Demographic	Age	0.92 (0.88-0.97)	< 0.001
	Gender (male vs female)	1.6 (0.36-6.9)	0.54
	Tobacco (yes vs no)	1.7 (0.48-5.8)	0.42
	Excess alcohol use (no vs yes)	1.1 (0.37-3.4)	0.83
	Family history liver cancer (yes vs no)	4.4 (1.6-11.9)	0.004
	Diabetes (yes vs no)	1.4 (0.42-5.0)	0.57
	Interval from tumor detection to OLT in mo	0.99 (0.91-1.07)	0.74
Disease groups	Recurrent liver cancer (yes vs no)	1.02 (0.29-3.5)	0.98
Preoperative laboratory tests	Total bilirubin	1.01 (1.004-1.01)	< 0.001
	Direct bilirubin	1.01 (1.01-1.01)	< 0.001
	Albumin	0.99 (0.90-1.10)	0.91
	Pre-albumin	0.91 (0.82-1.02)	0.11
	Alanine aminotransferase	1.00 (1.00-1.01)	0.57
	Asparate aminotransferase	1.00 (1.00-1.01)	0.15
	Prothrombin time	1.04 (0.92-1.2)	0.51
	Activated partial thromboplastin time	1.01 (0.96-1.08)	0.62
Tumor histopathology	Size of largest tumor (cm)	1.1 (1.03-1.2)	0.009
	Tumor staging	1.6 (0.43-6.2)	0.47
	Tumor range	1.3 (0.90-1.9)	0.16
	Tumor location (left vs right)	1.2 (0.33-4.0)	0.82
	Microembolism (micro vs none)	2.1 (0.67-6.7)	0.2
	Microembolism (macro vs none)	10.5 (2.3-48.3)	0.003
Preoperative staging	Child-Pugh Score	1.5 (0.67-3.4)	0.31
Intraoperative factors	OLT operative room time (h)	1.1 (0.80-1.6)	0.48
	OLT anhepatic time (min)	0.97 (0.92-1.01)	0.11
	OLT intra-op bleeding (L)	0.47 (0.20-1.1)	0.097
	OLT intra-op transfusion (L)	0.73 (0.43-1.2)	0.24
	OLT post-op transfusion (L)	1.1 (0.90-1.4)	0.33