Microsatellite alterations in phenotypically normal esophageal squamous epithelium and metaplasia-dysplasia-adenocarcinoma sequence

doi:10.3748/wjg.14.4070

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jul 7, 2008; 14(25): 4070-4076
Published online Jul 7, 2008. doi: 10.3748/wjg.14.4070

Table 1 Microsatellite alterations of un-diluted and diluted DNA in different esophageal tissues

Tissue DNA	Number studied	MSI			LOH
Tissue DNA	Number studied	Negative	At≥1 locus	At≥2 loci	Negative	At≥1 locus	At≥2 loci
Classification
SCC	23	12	5	6	17	3	3
ADC	18	11	4	3¹	15	2	1²
Normal
Undilution	8	8	0	0	8	0	0
Dilution	8	3	2	3³	4	2	2⁴
Metaplasia
Undilution	8	7	1	0	7	1	0
Dilution	8	1	4	3⁵	2	3	3⁶
Dysplasia
Undilution	8	7	1	0	7	1	0
Dilution	8	1	3	4⁷	2	2	4⁸
Carcinoma
Undilution	8	6	2	0	6	2	0
Dilution	8	0	3	5⁹	0	4	4¹⁰

Normal: Normal esophageal squamous epithelium DNA; Metaplasia: Barrett esophageal columnar epithelium DNA; Dysplasia: Dysplastic esophageal epithelium DNA; Carcinoma: Esophageal adenocarcinoma DNA;

¹P = 0.758,

²P = 0.696,

³P = 0.026,

⁴P = 0.069,

⁵P = 0.009, ⁶P = 0.034,

⁷P = 0.009,

⁸P = 0.029,

⁹P = 0.004,

¹⁰P = 0.004 vs other groups.

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Citation: Cai JC, Liu D, Liu KH, Zhang HP, Zhong S, Xia NS. Microsatellite alterations in phenotypically normal esophageal squamous epithelium and metaplasia-dysplasia-adenocarcinoma sequence. World J Gastroenterol 2008; 14(25): 4070-4076
URL: https://www.wjgnet.com/1007-9327/full/v14/i25/4070.htm
DOI: https://dx.doi.org/10.3748/wjg.14.4070

Cai JC, Liu D, Liu KH, Zhang HP, Zhong S, Xia NS. Microsatellite alterations in phenotypically normal esophageal squamous epithelium and metaplasia-dysplasia-adenocarcinoma sequence. World J Gastroenterol 2008; 14(25): 4070-4076 [PMID: 18609693 DOI: 10.3748/wjg.14.4070]

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