Autoantibodies in primary sclerosing cholangitis

Table 3 Prevalence of antibodies against a selection of specific neutrophil antigens in PSC patients

Antibody	Frequency range % (median)	No. of patients range (median)	Number of studies
Anti-lactoferrin	4-50 (29)	12-76 (24)	10[55578485878899102137144]
Anti-myeloperoxidase	0-33 (2)	12-73 (40)	7[577884858799102]
Anti-BPI	5-46 (29)	36-76 (69)	5[5557597899]
Anti-cathepsin G	0-35 (21)	14-76 (55)	5[5557848799]
Anti-proteinase 3	0-44 (4)	25-73 (62)	5[57788799102]
Anti-elastase	0-35 (9)	23-76 (69)	4[558799102]
Anti-α-enolase	11-33 (27)	15-55 (36)	3[5789147]
Anti-catalase	16-60 (38)	15-55 (35)	2[5789]
Anti-α-antigen	33 (33)	12 (12)	1[85]
Anti-h-lamp-2	71 (71)	73 (73)	1[78]
Anti-TBB51

PSC: Primary sclerosing cholangitis; Anti-BPI: Antibodies against bactericidal/permeability increasing protein; Anti-h-lamp-2: Antibodies against human lysosomal-associated membrane protein 2; Anti-TBB5: Antibodies against Tubulin beta-5 chain.

¹No prevalence studies published.