Ellagic acid induces apoptosis through inhibition of nuclear factor κB in pancreatic cancer cells

Figure 1 Ellagic acid stimulates apoptosis in pancreatic cancer cells. MIA PaCa-2 (A, C) and PANC-1 (B) cells were cultured for 48 h in the presence or absence of indicated doses of ellagic acid. Internucleosomal DNA fragmentation was measured using the Cell Death Detection ELISA kit (A, B); Dead cells were assessed by flow cytometry using AnV/PI staining (C). AnV⁺/PI^- and AnV⁺/PI⁺ cells were considered dying through apoptosis and/or secondary necrosis. Values are normalized to control (A, B). Values are mean ± SE (n = 3), ^aP < 0.05 vs control.