Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B12 status

doi:10.3748/wjg.14.3662

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Clinical Research

World J Gastroenterol. Jun 21, 2008; 14(23): 3662-3671
Published online Jun 21, 2008. doi: 10.3748/wjg.14.3662

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Figure 2 Representative examples of MSP reactions for promoter methylation analysis of p16, hMLH1, and hMSH2 genes in primary CLC tumors. The presence of a visible PCR product in those lanes marked U indicates the presence of unmethylated genes; the presence of a product in those lanes marked M indicates the presence of methylated genes. Lane 1 indicates the 50 bp DNA size marker.

Citation: Mokarram P, Naghibalhossaini F, Firoozi MS, Hosseini SV, Izadpanah A, Salahi H, Malek-Hosseini SA, Talei A, Mojallal M. Methylenetetrahydrofolate reductase C677T genotype affects promoter methylation of tumor-specific genes in sporadic colorectal cancer through an interaction with folate/vitamin B₁₂ status. World J Gastroenterol 2008; 14(23): 3662-3671
URL: https://www.wjgnet.com/1007-9327/full/v14/i23/3662.htm
DOI: https://dx.doi.org/10.3748/wjg.14.3662