Etiopathogenesis of primary biliary cirrhosis

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Jun 7, 2008 (publication date) through Apr 25, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Jun 7, 2008; 14(21): 3328-3337
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3328

Table 1 Immunopathological characteristics of biliary epithelium in PBC[90]

	Normal	PBC
Expression level of PDC-E2	+	+ + +
Adhesion molecules
- ICAM-1	+	+ +
- VCAM-1	-/+	+
- LFA-1	-/+	+
- E-selectin		+ +
Biliary intra-epithelial lymphocytes	Large bile ducts, few CD4⁺	Small bile ducts,increased CD4⁺CD28^-
Apoptosis-related molecules
- Fas (CD95)	-	+
- granzyme B	-	-/+
- perforin	-	-/+
- bcl-2	+ +	-
BEC phagocytosis of apoptotic BECs	-	+ +
Cytokines
- INF-γ	-	+ +
- IL-2	-	+ +
- IL-6	-	+ +
- IL-6 receptor	-	-/+
- TNF-α	-/+	+ +
- TNF receptor	-/+	+ +

Citation: Lleo A, Invernizzi P, Mackay IR, Prince H, Zhong RQ, Gershwin ME. Etiopathogenesis of primary biliary cirrhosis. World J Gastroenterol 2008; 14(21): 3328-3337
URL: https://www.wjgnet.com/1007-9327/full/v14/i21/3328.htm
DOI: https://dx.doi.org/10.3748/wjg.14.3328