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Copyright ©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jun 7, 2008; 14(21): 3313-3327
Published online Jun 7, 2008. doi: 10.3748/wjg.14.3313
Table 4 Pharmacological characteristics of the opiate antagonists investigated in clinical studies
Pharmacological characteristics
NaloxoneVery short half life
Intravenous continuous infusion
Dose: 0.2-0.4 &mgr;g/kg per minute
NalmefeneLonger half life
Oral administration
2 mg twice/d with a gradual increase until 20 mg twice/d
NaltrexoneLonger half life
Oral administration
50 mg/d
(in two divided doses the first day and subsequently in a unique dose)