Analysis of risk factors for the interval time, number and pattern of hepatic metastases from gastric cancer after radical gastrectomy

Table 2 Univariate and multivariate analysis of clinicopathologic factors potentially associated with the number of hepatic metastases after radical gastrectomy

		Cases of hepatic metastases after surgery
Factor	n	Solitary	Multiple	Univariate P value	Multivariate P value	Odds ratio
Age
≤ 50 yr	13	2	11	0.171	0.398	2.480
51-69 yr	55	9	46	-	-	-
≥ 70 yr	19	0	19	-	-	-
Gender
Male	77	10	67	0.798	0.732	0.392
Female	10	1	9	-	-	-
Gastric carcinoma
Size
≤ 5 cm	39	10	29	0.001	0.133	12.271
> 5 cm	48	1	47	-	-	-
Location
Proximal	25	3	22	0.678	0.539	1.487
Middle	17	1	16	-	-	-
Distal	43	7	36	-	-	-
Diffuse	2	0	2	-	-	-
Histologic differentiation
Poorly undifferentiated	42	4	38	0.398	0.797	1.359
Well, moderately	45	7	38	-	-	-
Vascular invasion
Absent	70	11	59	0.08	0.998	-
Present	17	0	17	-	-	-
Neural invasion
Absent	74	11	63	0.137	0.998	-
Present	13	0	13	-	-	-
Depth of invasion1
T1	4	3	1	< 0.001	0.046	8.799
T2	26	6	20	-	-	-
T3	48	2	46	-	-	-
T4	9	0	9	-	-	-
Lymph node metastases1
N1	31	7	24	0.060	0.991	0.989
N2	37	4	33	-	-	-
N3	19	0	19	-	-	-
No. 12 lymph node group metastases
Absent	75	11	64	0.156	0.998	-
Present	12	0	12	-	-	-
No. 8 lymph node group metastases
Absent	72	10	62	0.444	0.428	0.125
Present	15	1	14	-	-	-
Lauren classification
Intestinal	36	9	27	0.009	0.288	3.261
Diffuse	29	0	29	-	-	-
Mixed	22	2	20	-	-	-
Surgical procedure
Esophago-proximal	23	3	20	0.056	0.395	1.953
Proximal subtotal	8	1	7	-	-	-
Distal subtotal	45	7	38	-	-	-
Total	11	0	11	-	-	-
Ascites
Absent	57	8	49	0.338	0.718	0.544
Present	30	3	27	-	-	-
Soft tissue invasion
Absent	47	5	42	0.170	0.950	1.102
Present	40	6	34	-	-	-

¹According to pTNM classification of UICC; Esophago-proximal, resection of the distal esophagus and proximal stomach; total, resection of the whole stomach.