Anti-sense oligonucleotide labeled with technetium-99m using hydrazinonictinamide derivative and N-hydroxysuccinimidyl S-acetylmercaptoacetyltriglycline: A comparison of radiochemical behaviors and biological properties

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Apr 14, 2008 (publication date) through Jun 21, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Apr 14, 2008; 14(14): 2235-2240
Published online Apr 14, 2008. doi: 10.3748/wjg.14.2235

Table 2 Radiochemical stability of labeled compounds (%, mean ± SD)

	Incubation time at room temperature (h)			Incubation time at 37°C (h)
	1	2	4	1	2	4
^99mTc-HYNIC-ASON	93.43 ± 5.32	89.17 ± 4.62	87.16 ± 5.36	92.75 ± 4.46	89.52 ± 3.67	86.86 ± 5.49
^99mTc-MAG₃-ASON	97.26 ± 6.02	96.68 ± 5.54	96.39 ± 4.68	95.86 ± 5.69	95.47 ± 4.07	94.79 ± 5.34

Citation: Li YC, Tan TZ, Zheng JG, Zhang C. Anti-sense oligonucleotide labeled with technetium-99m using hydrazinonictinamide derivative and N-hydroxysuccinimidyl S-acetylmercaptoacetyltriglycline: A comparison of radiochemical behaviors and biological properties. World J Gastroenterol 2008; 14(14): 2235-2240
URL: https://www.wjgnet.com/1007-9327/full/v14/i14/2235.htm
DOI: https://dx.doi.org/10.3748/wjg.14.2235