Crosstalk between tumor cells and microenvironment via Wnt pathway in colorectal cancer dissemination

Figure 1 Schematic illustration of the canonical Wnt/β-catenin signaling pathway. A: In the absence of Wnt ligands, destruction complex phosphylates β-catenin for ubiquitination and proteolytic degradation; B: In the presence of Wnt ligands, formation of destruction complex is not accomplished, resulting in nuclear translocation of β-catenin.