Genome-wide differences in hepatitis C- vs alcoholism-associated hepatocellular carcinoma

Table 1 Clinical data from patients with HCC or controls

Patient1	Sex	Age	Pathology	Etiology2	Tumor grade3	Number of nodules4	Nodule size (cm)	Vascular invasion	Lymphocyte infiltration5
V1	F	71	HCC	HCV	3	2	4; 5	Yes	0
V3	F	67	HCC	HCV	3	1	2.5	No	+++
V4	F	72	HCC	HCV	3	1	4	No	+++
V8	M	66	HCC	HCV	3	1	4	Yes	++
V9	M	65	HCC	HCV	3	2	1.5; 3	No	+
V14	M	63	HCC	HCV	2	1	2	No	0
V15	M	70	HCC	HCV	1	1	3.5	No	+++
V17	M	69	HCC	HCV	3	1	2.5	No	+++
V20	F	73	HCC	HCV	3	1	1.5	Yes	++
V21	M	65	HCC	HCV	2	1	2	No	+
V23	F	68	HCC	HCV	2	2	1; 5.5	Yes	0
V24	M	80	HCC	HCV	1; 3	2	2.5; 3.5	No	0
V25	M	64	HCC	HCV	3	2	2; 5.5	Yes	+++
V26	M	46	HCC	HCV	3	1	2.5	Yes	+
V27	M	55	HCC	HCV	3	2	3; 3.5	Yes	0
V28	M	55	HCC	HCV	2	2	4; 4	No	++
V35	M	53	HCC	HCV	2; nd; nd	3	7; nd; nd	Yes	+
A2	M	68	HCC	ALC	2	1	11	No	0
A5	M	79	HCC	ALC	2	1	6	No	++
A6	M	63	HCC	ALC	2	1	3	No	+
A7	M	49	HCC	ALC	1	1	2	No	0
A10	M	73	HCC	ALC	2	1	5	No	+
A11	M	50	HCC	ALC	2	1	4.5	No	+
A12	M	64	HCC	ALC	1	1	2.5	No	+
A13	M	72	HCC	ALC	3	1	2.5	Yes	++
A16	M	56	HCC	ALC	3	1	8.5	Yes	++
A18	M	70	HCC	ALC	2	1	3.5	No	+
A19	M	70	HCC	ALC	3	1	2.5	No	+++
A22	M	78	HCC	ALC	1	1	1.7	No	+
A29	M	66	HCC	ALC	2	1	7	No	+
A30	M	55	HCC	ALC	2	1	4.5	No	0
A31	M	56	HCC	ALC	2	1	4	Yes	0
A32	F	66	HCC	ALC	3	1	8	No	0
A33	M	55	HCC	ALC	3	1	15	Yes	0
A34	M	69	HCC	ALC	3	1	2.2	Yes	0
C1	M	74	AD6	-
C2	F	45	AD	-
C3	F	68	AD	-
C4	F	43	AD+FNH6	-
C5	F	30	FNH	-

¹V1 to A34, patients with cirrhosis and HCC, A or V refers to the alcoholic or viral etiology. C1 to -5, control patients. Patients V1 to V21 and A2 to A22 were first studied by microarray, and next used as a training set for SVM.

²HCV: Hepatitis C virus infection; ALC: Alcohol abuse; -: None.

³Differentiation grade; nd: Not determined.

⁴In multinodular HCCs, only 1 nodule was studied.

⁵Nodular infiltration; semi-quantitative appraisal done by a trained anatomopathologist (AF).

⁶Histologically normal liver taken away from a benign adenoma (AD) or a focal nodular hyperplasia (FNH).