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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Jan 7, 2008; 14(1): 38-45
Published online Jan 7, 2008. doi: 10.3748/wjg.14.38
Published online Jan 7, 2008. doi: 10.3748/wjg.14.38
Table 4 Genotype distribution of non-synonymous ABCB11 variant site 1331T>C in patients and controls
| Genotype SNP | ICPold | ICPnew | ICPtotal | Pregnant controls | Caucasian controls | |||||
| n(%) | 95 % CI | n(%) | 95 % CI | n(%) | 95 % CI | n(%) | 95 % CI | n(%) | 95 % CI | |
| ABCB11 1331T>C (V444A) | 21 (100) | 21 (100) | 42 (100) | 40 (100) | 205 (100) | |||||
| TT (VV) | - | - | 2 (9.5) | 0.0-22.1 | 2 (4.8) | 0.0-13.9 | 7 (17.5) | 5.7-29.3 | 38(18.5) | 13.2-23.9 |
| CC (AA) | 14 (67.7) | 46.5 -86.8 | 10 (47.6) | 26.3-69.0 | 24 (57.1) | 36.0-78.3 | 8 (20) | 7.6-32.4 | 66 (32.2) | 25.8-38.6 |
| TC (VA) | 7 (33.3) | 13.2-53.5 | 9 (42.9) | 21.7-64.0 | 16 (38.1) | 17.3-58.9 | 25 (62.5) | 47.5-77.5 | 101 (49.3) | 42.4-56.1 |
| Frequency C allele | 35 (83.3) | 67.4-99.3 | 29 (69.0) | 49.3-88.8 | 64 (76.2) | 58.0-94.4 | 41 (51.3) | 35.8-66.7 | 233 (56.8) | 50.1-63.6 |
| Frequency T allele | 7 (16.7) | 0.7-32.6 | 13 (31.0) | 11.2-50.7 | 20 (23.8) | 5.6-42.0 | 39 (48.8) | 33.3-64.2 | 177 (43.2) | 36.4-50.0 |
| ABCC2 3563T>A (V1188E) | 16 (100) | 17 (100) | 33 (100) | 42 (100) | 110 (100) | |||||
| TT (VV) | 15 (93.8) | 71.3-98.6 | 13 (76.5) | 52.3-90.4 | 28 (84.8) | 68.9-93.3 | 37 (88.1) | 74.3-96.1 | 95 (86.4) | 68.9-93.3 |
| AA (EE) | - | - | - | - | - | - | - | - | 1 (0.9) | 0.0-5.0 |
| TA (VE) | 1 (3.1) | 0.0-15.8 | 4 (23.5) | 9.6-47.7 | 5 (15.2) | 6.7-31.1 | 5 (11.9) | 3.9-25.7 | 14 (12.7) | 7.1-20.5 |
| ABCC2 4544G>A (C1515Y) | 16 (100) | 17 (100) | 33 (100) | 42 (100) | 110 (100) | |||||
| GG (CC) | 15 (93.8) | 71.3-98.6 | 13 (76.5) | 52.3-90.4 | 28 (84.8) | 68.9-93.3 | 36 (85.7) | 71.4-94.6 | 95 (86.4) | 68.9-93.3 |
| AA (YY) | - | - | - | - | - | - | - | - | 1 (0.9) | 0.0-5.0 |
| GA (CY) | 1 (3.1) | 0.0-15.8 | 4 (23.5) | 9.6-47.7 | 5 (15.2) | 6.7-31.1 | 6 (14.3) | 5.4-28.6 | 14 (12.7) | 7.1-20.5 |
- Citation: Meier Y, Zodan T, Lang C, Zimmermann R, Kullak-Ublick GA, Meier PJ, Stieger B, Pauli-Magnus C. Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump. World J Gastroenterol 2008; 14(1): 38-45
- URL: https://www.wjgnet.com/1007-9327/full/v14/i1/38.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.38