Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump

Table 2 New group of patients with ICP (ICP_new)

Patient ID	Age (yr)	Liver parameters					Comments		Genotypes of SNPs
		ALT (ULN)	AP (ULN)	γ-GT (ULN)	tBili (ULN)	tBA (ULN)	No of preg/No ICP	Others	ABCB111331T>C (V444A)	ABCC23600T>A (V1188E)	ABCC24581G>A (C1515Y)
1	36	0.9	2.3	3.3	0.8	10.7	2/1		CC	TA	GA
2	31	1.6	2.5.	0.3	0.8	17.3	3/2		TC	TA	GA
3	35	8.9	2.3	1	0.5	10	1/1		TC	TT	GG
4	29	1.2	3	0.6	0.5	7	2/1		CC	TT	GG
5	42	11.6	1.4	0.4	0.8	6	1/1		TC	TT	GG
6	28	4.8	1.8	0.2	0.8	4.7	2/1	Twins	CC	TA	GA
7	32	11.9	3	1.2	0.9	3.6	nd		CC	TT	GG
8	16	5.2	2	0.4	nd	3.3	nd		TC	TT	GG
9	38	6.2	1.2	1.1	0.4	3	2/1		TC	TT	GG
10	23	1.6	1.3	1.3	0.8	2.4	1/1	Twins	TC	TT	GG
11	30	0.4	0.9	0.2	0.5	2.4	3/1		TC	TT	GG
12	22	0.3	1.8	0.1	0.5	2.1	nd		TC	TA	GA
13	32	0.2	0.9	0.7	0.2	2	2/1		TT	TT	GG
14	30	0.8	1.2	0.3	0.6	1.7	1/1		CC	TT	GG
15	28	7.5	2.3	0.9	0.6	nd	nd		TC	TT	GG
16	31	0.9	2.1	1.2	0.5	8.1	1/1		CC	TT	GG
17	20	3.4	1.1	0.4	0.5	2.6	1/1		TT	T	GG
18	24	7.2	1.3	0.4	0.8	nd	1/1		CC	nd	nd
19	31	8.9	1.3	1.2	1.5	nd	2/2		CC	nd	nd
20	32	11	2.2	0.4	3.1	nd	3/3	Pruritus with contraceptives	CC	n	nd
21	41	10.9	2.9	5.7	1.2	nd	1/1	Twins	CC	nd	nd
Summary median (Q1; Q3)	31 (28; 32)	4.8 (0.9; 8.9)	1.8 (1.2; 2.3)	0.6 (0.4; 1.2)	0.6 (0.5; 0.8)	3.5 (2.4; 7.3)

n/a: Not available; ALT: Alanine aminotransferase; tBili: Total bilirubin; tBA: Total bile acids.