New aspects in celiac disease

Table 3 Future directions in celiac disease

Unanswered questions	Future directions
Immunopathogenesis
How is oral tolerance broken?	Restoring immunological tolerance to gluten would represent the ideal cure for CD
Gluten-specific T cells	Gluten-specific T cells could be inactivated or deleted, tolerance to gluten should be restored
Diagnosis
What is the significance of the vast number of currently undiagnosed people with the disease?	The rate of the diagnosis will continue to increase with better diagnosis.
What is the significance of the increase number of people with extraintestinal symptoms or without classical symptoms in CD?	“the suspicion of the disease”
Genetics
Identify the genetic risk factors that predispose to CD	Polymorphic genes located in the MHC region and CD
	Genetic polymorphism of cytokine genes may influence the risk of CD
	Associated polymorphism with serological markers
	HLA-G polymorphism?