Proteasome inhibition-induces endoplasmic reticulum dysfunction and cell death of human cholangiocarcinoma cells

Figure 1 Morphologic assessment of MG132 induced death in KMCH, KMBC and Mz-ChA-1 cholangiocarcinoma and normal rat cholangiocytes (NRC) cell lines. A: MG132 induces apoptosis in all cholangiocarcionoma cell lines was maximal (> 90%) with a MG132 concentration of 10 (μmol/L); B: MG132 (1 μmol/L) induced apoptosis in the human KMCH cholangiocarcinoma cell line, but not in the nontransformed NRC cells; C: Apoptosis had the classic nuclear appearance as assessed by DAPI staining and fluorescence microscopy.