Imatinib-induced fatal acute liver failure

Table 2 Summary of previously reported cases of serious (fatal and non-fatal) drug-induced liver damage following treatment with imatinib mesylate

Reference	Diagnosis	Time tohepaticdysfunction	Liverhistology	Outcome ofliver enzymes
Ohyashiki et al (2002)	CML	12 d	Focal necrosis of hepatocytes	Resolution after stopping drug
Lin et al (2003)	Polycythemia vera	7 wk	Hepatic necrosis	Patient died fatal acute hepatic necrosis
James et al (2003)	CML	49 wk	Acute severe cytolytic hepatitis.	Resolution after stopping drug
			With necrosis and mild cholestasis
	CML	22 wk	Acute cytolytic hepatitis with spotty and some piecemeal necrosis	Resolution after stopping drug
Kikuchi et al (2004)	CML	36 wk	Hepatic necrosis	Resolution after stopping drug
Ayoub et al (2005)	CML	2 yr	Portal and lobular inflammation.	Resolution after stopping drug
			Bridging and multifocal lobular necrosis
Cross et al (2007)	CML	77 wk	Severe necrosis with multilobular confluent cell dropout and reticulin collapse, multinodular regeneration	Patient died 10 d after liver transplantation
Ridruejo et al (2007)	CML	22 wk	Not available	Patient died fatal acute hepatic necrosis