Moving forward in colorectal cancer research, what proteomics has to tell

Table 2 Proteomic analysis in human colorectal cancer tissues

Up-regulated		Down-regulated
Annexin IV		NCF2
MTA-1		PMM2
SSX5 protein		Serpin 1
Dynein heavy chain		CNRC
Cytochrome P450		Annexin V
CPT1		APC
Keratin 10		VAV3 protein
Keratin 8		RSP 4
Keratin 19		SPARC like protein 1
Vimentin		PDI
β-actin		GN6ST
REL1		Cathepsin D
HSP60		Calreticulin
Mortalin	Cathepsin fragment	SM31
		PDA6
	Proteasome subunit a type 6	ApoA1 precursor
Cytochrome P450 enzymes (in cancer tissues and metastatic tissues)		ATP synthase b chain
	Triosephosphate isomerase 14-3-3 proteins	Albumin
		Liver fatty acid-binding protein
HSP70	GST-P	Actin-binding protein/smooth muscle protein 22-a
S100A9
S100A8	P13693 translationally controlled tumor protein	Cyclooxygenase 2
S100A11
S100A6		Puromycin-sensitive aminopeptidase
	Nucleoside diphosphate kinase A
		NADH-ubiquinone oxidoreductase
Adenosyl homocysteinase	Calgranulin B; S100 A9
Leukocyte elastase inhibitor, claude B		Succinate dehydrogenase subunit A
Macrophage capping protein
Biliverdin reductase A		Aldehyde dehydrogenase, cytosolic, class I
Annexin 1 fragment
α-tubulin
Elongation factor 1-d		Selenium-binding protein
Tropomyosin a1		Creatin kinase B chain
Tropomyosin a4 chain		Placental thrombin inhibitor
Actin fragment		Vimentin
Annexin 5		Desmin
Microtuble-associated protein RP/EB		Tubulin b 5 chain
Pyridoxal kinase		Carbonic anhydrase I
Annexin 3		Myosin regulatory light chain 2
Annexin 4