Sequential algorithms combining non-invasive markers and biopsy for the assessment of liver fibrosis in chronic hepatitis B

Table 1 Demographic, laboratory and histological characteristics of the 110 patients with chronic hepatitis B

Males n (%)	80 (72.7)
Age (mean yr ± SD)	42.6 ± 11.3
BMI (kg/m2)	24.2 ± 3.3
AST (mean IU/L ± SD)	73.4 ± 61.2
AST / ULN ratio (mean ± SD)	1.75 ± 1.47
ALT (mean IU/L ± SD)	144.5 ± 148.0
ALT / ULN ratio (mean ± SD)	3.14 ± 3.3
γGT (mean IU/L ± SD)	46.4 ± 49.1
γGT / ULN ratio (mean ± SD)	0.81 ± 0.84
Bilirubin (mean μmol/L ± SD)	13.9 ± 6.48
PLT (mean 109/L ± SD)	194.6 ± 56.9
Albumin (mean g/L ± SD)	42.7 ± 5
Cholesterol (mean mg/dL ± SD)	177.5 ± 32.9
INR (mean value ± SD)	1.12 ± 0.1
Haptoglobin (mean g/L ± SD)	1.05 ± 0.6
α2M (mean g/L ± SD)	2.67 ± 0.84
ApoA1 (mean g/L ± SD)	1.48 ± 6.48
Viral load (mean log10 cp/mL ± SD)	2.15 ± 1.18
HBeAg positive cases (%)	20 (18.2)
HDV co-infected cases (%)	8 (7.3)
Staging n (%)
F0	15 (13.6)
F1	20 (18.2)
F2	40 (36.4)
F3	13 (11.8)
F4	22 (20.0)

SD: standard deviation; ULN: upper limits of normal;PLT: platelets; INR: international normalised ratio; α₂M: alpha-2-macroglobulin; ApoA1: apolipoprotein A1.