Fever as the only manifestation of hypersensitivity reactions associated with oxaliplatin in a patient with colorectal cancer Oxaliplatin-induced hypersensitivity reaction

Table 2 Incidence of HSR in pivotal studies of oxaliplatin in metastatic and adjuvant treatment of colorectal cancer

Study	Number of patients	Patients with HSR (%)	Patients with Grade 3/4 HSR (%)
Data from first-line[10]	259	12	2
Data from second-line[10]	150	10	< 1
MOSAIC (adjuvant)[2]	1123	10.3	2.9
Siu et al[1] all patients	180	15	2.2
Siu et al[11] adjuvant/ first-line metastatic	88	10.2
Siu et al[11] second-line metastatic	92	19.6

HSR: Hypersensitivity reactions.