A novel phenol-bound pectic polysaccharide from Decalepis hamiltonii with multi-step ulcer preventive activity

Table 2 Gastric mucin and H⁺, K⁺-ATPase levels in healthy, ulcerated and protected rats (n = 6) mean ± SD

Group, n = 6	Mucin content (mg/g)	H+, K+-ATPase (μmoles Pi released/mg/h)
Healthy	45.04d± 4.128	0.807d± 0.072
Swim stress induced ulcer model
Swim stress induced	17.78a± 2.557	2.209a± 0.152
SRPP 100 mg/kg b.w.	27.13b± 4.082	1.771b± 0.081
SRPP 200 mg/kg b.w.	35.35c± 3.221	1.601b± 0.091
Ranitidine 50 mg/kg b.w.	31.42b,c± 2.327	1.621b± 0.092
Ethanol stress induced ulcer model
Ethanol stress induced	16.32a± 3.821	2.621a± 0.211
SRPP 100 mg/kg b.w.	32.13b± 3.457	2.123b± 0.241
SRPP 200 mg/kg b.w.	39.53b,c± 3.082	1.512c± 0.121
Ranitidine 50 mg/kg b.w.	37.13b± 1.507	1.485c± 0.124

Different letters a to d in the column represents that values are significantly different when compared between ulcer induced with healthy control and SRPP/Ranitidine treated groups. Range was provided by Duncan multiple test at P < 0.05. a: Less significant; b: Moderately significant; c: Very significant and d: Most significant.