Does protracted antiviral therapy impact on HCV-related liver cirrhosis progression?

Table 2 Child-Pugh classification (slightly modified)

Clinical and laboratory data	Points for increasing abnormality1
	1	2	3
HE (grade2)	None	(SHE)0-1-2	3-4
Ascites	None at US	Mild or controlled by diuretics	Present despite diuretics
PT (% of activity)3	> 70	70-40	< 40
Albumin (g/dL)	> 3.5	2.8-3.5	< 2.8
Bilirubin (mg/dL)	< 2	2-3	> 3

¹Scoring system: 5-6 points, grade A; 7-9 points, grade B; 10-15 points, grade C.

²HE: hepatic encephalopathy; Grade 0: sub-clinical hepatic encephalopathy, SHE, unravelled by retain tests A or B; Grade 1: anxiety, irritability, depression, impaired concentration, sleep disturbances; Grade 2: disorientation, poor short-term memory, disinhibited behaviour, drowsiness; Grade 3: somnolence, bizarre behaviour, confusion, amnesia, paranoia; Grade 4: Coma.

³PT, prothrombin time, also expressed in seconds prolonged < 4; 4-6; > 6, or as INR < 1.7; 1.7-2.3; > 2.3. US: ultra sound.