CD4+ T cell responses in hepatitis C virus infection

Table 1 Displays the most commonly described CD4+ restricted epitopes

Amino acid position	HCV protein	Amino acid sequence	HLA-restriction	Reference
aa 21-40	Core	DVKFPGGGQIVGGVYLLPRR	DRB1*1101,DQB1*0301	Day, 2002
aa 31-45	Core	VGGVYLLPRR GPRLG	DRB1*1101	Godkin, 2001
aa 141-155	Core	GAPLGGAARA LAHGV	DRB1*1101	Godkin, 2001
aa 393-410	E2	GFATQRLTSLFALGPSQK	DRB1*1101	Frasca, 1999
aa 1241-1260	NS3	PAAYAAQGYKVLVLNPSVAA	DRB1*15, DRB1*0301 +	Day, 2002
aa 1248-1261	NS3	GYKVLVLNPSVAAT	DR4, DRB1*1101	Wertheimer, 2003
aa 1248-1267	NS3	GYKVLVLNPSVAATLGFGAY	DQB1*0301	Lamonaca, 1999
aa 1251-1259	NS3	VLVLNPSVA	DRB1*1101,DRB1*1201, DRB1*0401, DRB1*1302	Day, 2002
aa 1384-1401	NS3	VIKGGRHLIFCHSKKKCD	DRB1*15	Eckels. 1999
aa 1411-1426	NS3	GINAVAYYRGLDVSVI	DRB1*15	Gerlach, 2005
aa 1531-1550	NS3	TPAETTVRLRAYMNTPGLPV	DRB1*0701	Day, 2002
aa 1539-1554	NS3	LRAYMNTPGLPVCQDH	DRB1*15	Gerlach, 2005
aa 1581-1600	NS3	ENLPYLVAYQATVCARAQAP	DRB1*1001	Day, 2002
aa 1686-1705	NS4a	VVLSGKPAIIPDREVLYREF	DRB1*0301	Harcourt, 2003
aa 1746-1765	NS4b	IAPAVQTNWQKLETFWAKHM	DRB1*16 or DRB3*0202	Harcourt, 2003
aa 1767-1786	NS4b	NFISGIQYLAGLSTLPGNPA	DRB1*1104	Carlos, 2004
aa 1771-1790	NS4b	GIQYLAGLSTLPGNPAIASL	DRB1*0404	Day, 2002
aa 1806-1818	NS4b	TLLFNILGGWVAA	DRB1*0101	Gerlach, 2005
aa 1907-1926	NS4b	GPGEGAVOWMNRLIAFASRG	DRB1*1104,DQB1*0501	Lamonaca, 1999
aa 2268-2282	NS5a	VSVPAEILRK SRRFA	DRB1*1101	Godkin, 2001
aa 2571-2590	NS5b	KGGRKPARLIVFPDLGVRVC	DRB1*0404,DRB1*0407	Day, 2002
aa 2841-2860	NS5b	ARMILMTHFFSVLIARDQLE	DRB1*1101	Day, 2002
aa 2941-2955	NS5b	CGKYLFNWAV RTKLK	DRB1*1101	Godkin, 2001
aa 2941-2960	NS5b	CGKYLFNWAVRTKLKLTPIA	DRB1*1101	Day, 2002