Pathology of hepatic iron overload

Table 3 Main causes of hepatic iron overload according to the histological type of siderosis and associated lesions

Parenchymal iron overload
	With normal liver
		Early genetic hemochromatosis
		Nontransfused dysmyelopoiesis
		Hereditary aceruloplasminemia
	With cirrhosis
		Iron overload secondary to cirrhosis
Mixed iron overload
	With normal liver
		Insulin resistance syndrome
		Ferroportin disease
		Transfused dysmyelopoiesis
		Oral or parenteral iron supplementation
	With steatosis or steatohepatitis
		Insulin resistance syndrome
		Chronic alcoholism
	With chronic hepatitis
		Hepatitis C or B
		Wilson's disease
	With intrahepatocytic inclusions
		Porphyria cutanea tarda
	With cirrhosis
		Late genetic hemochromatosis
Mesenchymal iron overload
	With normal liver
		Inflammatory syndrome
		Repeated transfusions