HFE gene in primary and secondary hepatic iron overload

Table 2 Studies of the relationship between chronic hepatitis C, iron and HFE mutations

Reference	Casesn	Ethnicity	HFErelationshipwith serumiron indices	HFErelationshipwith HI	HFErelationshipwith fibrosis
[70]	206	Italian	Yes	Yes	Yes
[83]	120	Mostly Swiss and Italian	No	No	No
[88]	242	Mostly Caucasian	No	No	No
[89]	164	Mostly Caucasian	No	No	No
[90]	137	Caucasian	Yes	Yes	Yes
[91]	135	Brazilian	Yes	Yes	Yes
[92]	119	Mostly Caucasian, non-Hispanic	Yes	Yes	Yes
[93]	316	Mostly White	Yes	Yes	Yes
[94]	401	Mostly German	Yes	Yes	Yes
[95]	184	White, non-Hispanic	Yes	No	No
[96]	273	NA	Yes	Yes (only H63D)	No
[97]	1051	Mostly White, non-Hispanic	Yes	Yes	No

NA: not available; HI: hepatic iron (histological and/or biochemical evidence).