HFE gene in primary and secondary hepatic iron overload

Table 1 Nomenclature for iron overload states

Primary iron overload-hereditary haemochromatosis (HH)

HFE-associated HH

1 C282Y homozygosity

2 C282Y/H63D compound heterozygosity

3 Other mutations

Non HFE-associated HH

1 Juvenile haemochromatosis

2 TfR2-related haemochromatosis

3 Autosomal dominant haemochromatosis

Secondary iron overload-acquired

Iron-loading anaemias

1 Thalassaemia major

2 Sideroblastic anaemia

3 Chronic haemolytic anaemias

Chronic liver diseases

1 Hepatitis C

2 Alcoholic liver disease

3 Non-alcoholic steatohepatitis

4 Porphyria cutanea tarda

5 IR-HIO

6 Post-portacaval shunting

7 Transfusional and parenteral iron overload

8 Dietary iron overload

Miscellaneous

1 Iron overload in sub-Saharan Africa

2 Neonatal iron overload

3 Acaeruloplasminaemia

4 Congenital atransferritinaemia