Changes in gene-expression profiles of colon carcinoma cells induced by wild type K-ras2

Table 2 Biological function of genes with up-regulated expression

Gene	Chromosomal localization	Biological function	Cy5/Cy3
SZF1	3p21	Transcriptional control	0.181
MMP14	14q11-q12	Incision enzyme, proteolysis	0.186
WIT-1	11p13	Cell proliferation	0.189
LOC253012	7q21.3	Gas exchange, cell adhere, early nerve difference and axonogenesis	0.201
OPCML	11q25	Cell adhere, nerve identification	0.239
PLAU	10q24	Chemotaxis, proteolysis, transduction	0.258
MYC	8q24.12-q24.13	Positive-regulated cell proliferation, inhibit cell cycle, balance of iron ion, mRNA synthesis control	0.274
SNTB1	8q23-q24	Muscle contraction, skelet-matrix adhere	0.281
SERPINESL	7q21.3-q22	Ser incision enzyme inhibitor, cell component, angiogenetic regulation	0.290
C20A1	2q11-q14	PCD transport, cell component	0.294
SPTBN1	2p21	Cytokeleton	0.298
GNAS	20q13.2-q13.3	Energy metabolism, G-protein signal pathway, signal transduction	0.302
PCOLCE	7q22	Proteolysis, cell component	0.303
ENPP2	8q24.1	Cell movement, G-protein signal pathway, phosphorylation metabolism, lytic activity p'tase activity, transcription	0.309
CDK6	7q21-q22	Proliferation, cell cycle, protein conjunct	0.315
HIST2H2BE	1q21-q23	Chromosome component and synthesis	0.323
ZNF137	19q13.4	Transcription control, ion binding	0.332
IL1B	2q14	Inflammation, proliferation, chemotaxis	0.336
IL1A	2q14	Apoptosis, proliferation, transduction, chemotaxis	0.343
MTSS1	8p22	Actin component and synthesis, cell adhere, cell movement, PTK signal pathway, muscle and NS development, internalization	0.346
ACHE	7q22	Muscle contraction, transduction	0.353
EPHB4	7q22	Proliferation, organ-formation, angiogenesis	0.368
AZGP1	7q22.1	Cell member component	0.376
PDE4DIP	1q12	Protein synthesis, actin component	0.377
PITPN	17p13.3	PHL transport	0.379
MEOX1	17q21	Growth	0.386
GNB2L1	5q35.3	Intercellular signal cascade reaction, protein localization, transduction, PKC	0.394
MERTK	2q14.1	Transduction, cross-cell signal transmission, protein phosphorylation	0.405
CUTL1	7q22.1	Transcription control	0.419
FCGR2A	1q23	Immune reaction, signal switch, defence reaction, B cell proliferation	0.428
PAX8	2q12-q14	Organ-formation, transcription control, metanephros development, mRNA synthesis	0.442