H pylori seropositivity and cytokine gene polymorphisms

Table 4 Age, gender-adjusted ORs for H pylori seropositivity according to cytokine genotypes and lifestyle factors

	IL1B–511C/T
	n	Hp (+)%1	C/C	C/T	P-value	T/T	P-value
All subjects	410	57.8	1.00	0.69 (0.43-1.10)	0.121	0.70 (0.37-1.32)	0.270
Smoking
Never	91	64.8	1.00	0.30 (0.10-0.90)	0.032	0.40 (0.10-1.62)	0.200
Former	133	57.1	1.00	0.90 (0.39-2.10)	0.819	0.74 (0.26-2.15)	0.583
Current	186	54.8	1.00	0.83 (0.42-1.63)	0.582	0.80 (0.30-2.16)	0.658
Drinking
Never or rarely	78	44.9	1.00	0.58 (0.20-1.66)	0.310	1.38 (0.31-6.23)	0.676
1-5 times/wk	222	59.0	1.00	0.81 (0.43-1.55)	0.531	0.38 (0.16-0.95)	0.039
6-7 times/wk	110	64.5	1.00	0.66 (0.25-1.69)	0.383	1.11 (0.33-3.77)	0.862
	IL1B–31C/T
	n	Hp (+)%1	C/C	C/T	P-value	T/T	P-value
All subjects	410	57.8	1.00	1.11 (0.61-2.05)	0.726	1.47 (0.78-2.78)	0.234
Smoking
Never	91	64.8	1.00	0.79 (0.22-2.29)	0.723	2.25 (0.56-9.08)	0.257
Former	133	57.1	1.00	1.34 (0.50-3.62)	0.560	1.55 (0.55-4.42)	0.409
Current	186	54.8	1.00	1.20 (0.44-3.24)	0.722	1.22 (0.44-3.40)	0.705
Drinking
Never or rarely	78	44.9	1.00	0.44 (0.11-1.82)	0.258	0.68 (0.15-3.12)	0.624
1-5 times/wk	222	59.0	1.00	2.59 (1.04-6.47)	0.042	3.17 (1.23-8.14)	0.017
6-7 times/wk	110	64.5	1.00	0.72 (0.23-2.29)	0.579	0.81 (0.24-2.73)	0.735
	IL6–634C/G
	n	Hp (+)%1	C/C	C/G	P-value	G/G	P-value
All subjects	410	57.8	1.00	1.06 (0.68-1.66)	0.785	0.63 (0.24-1.62)	0.335
Smoking
Never	91	64.8	1.00	0.54 (0.22-1.38)	0.200	2.79 (0.28-27.73)	0.382
Former	133	57.1	1.00	0.63 (0.28-1.41)	0.259	0.00 (0.00)	0.999
Current	186	54.8	1.00	2.28 (1.13-4.58)	0.021	0.84 (0.22-3.15)	0.796
Drinking
Never or rarely	78	44.9	1.00	1.07 (0.41-2.82)	0.886	0.00 (0.00)	1.000
1-5 times/wk	222	59.0	1.00	1.02 (0.55-1.91)	0.940	0.40 (0.11-0.41)	0.153
6-7 times/wk	110	64.5	1.00	1.61 (0.63-4.12)	0.325	1.60 (0.28-9.28)	0.599

¹H pylori seropositivity (%).