Assessment of drug-induced hepatotoxicity in clinical practice: A challenge for gastroenterologists

Table 6 Comparison of the scores for individual axes of the CIOMS and Maria & Victorino diagnostic scales

CIOMS criteria	Score	Maria & Victorino criteria	Score
Chronology criterion		Chronology criterion
From drug intake until event onset	+2 to +1	From drug intake until event onset	+1 to +3
From drug withdrawal until event onset	+1 to 0	From drug withdrawal until event onset	-3 to +3
Time-course of the reaction	-2 to +3	Time-course of the reaction	0 to +3
Risk factors		Exclusion of alternative causes	-3 to +3
Age	+1 to 0
Alcohol	+1 to 0	Extra-hepatic manifestations	0 to +3
Concomitant therapy	-3 to 0	Literature data	-3 to +2
Exclusion of non-drug-related causes	-3 to +2	Re-challenge	0 to +3
Literature data	0 to +2
Re-challenge	-2 to +3