Telomerase activity in colorectal cancer, prognostic factor and implications in the microsatellite instability pathway

Table 3 Univariate analysis OS

Variable	OS (40 mo, %)		HR1	95% CI	P
Sex	Men	63	1.7	0.75-3.84	0.19
	Female	77
Age	≥ 71 yr	68	1.19	0.54-2.62	0.65
	< 71 yr	71
Dukes stage	A+B	95			< 0.0001
	C	83	3.4	0.63-18.90
	D	5	48.08	11.03-209.5
Site	Colon	70			0.73
	Rectum	67	1.16	0.50-2.70
Colon site	Proximal	67	1.23	0.47-3.24	0.66
	Distal	74
Grade	I	78			0.27
	II	59	2.04	0.84-4.94
	III	66	1.49	1.19-11.58
Histological	Adenocarcinoma 72				0.29
type	Mucoid	46	1.88	0.66-5.55
Chemo	Yes	63	2.06	0.82-5.18	0.10
therapy	No	82
MSI	MSS	70			0.94
	MSI-L	62	1.11	0.33-3.74
	MSI-H	75	0.77	0.10-5.77
Telomerase	Positive	67	22.93	0.04-12.084	0.04
	Negative	100

MSS: absence of microsatellite instability; MSI-L: low instability; MSI-H: high instability; OS: overall survival; HR: hazard ratio; 95% CI: 95% confidence interval.

¹HR are adjusted for the variables of the table. Median follow-up time: 40 mo. Cox analysis. Statistically significant: P < 0.05.