Immunohistochemical molecular markers as predictors of curability of endoscopically resected submucosal colorectal cancer

Table 1 LN Metastasis in relation to clinicopathologic features of submucosal CRC

Clinicopathologic	features	n	LN positive (%)	P value
Size (mm)	≤ 20	159	20 (12.6)	NS
	> 20	55	8 (14.6)
Location	Rectum	61	8 (13.1)	NS
	Colon	153	20 (13.1)
Macroscopic type	Protruded type	145	14 (9.7)	0.0311
	Superficial type	69	14 (20.3)
Depth of invasion (μm)	< 1000	25	1 (4.0)	NS
	≥ 1000	189	27 (14.3)
Histologic grade	Favorable	198	22 (11.1)	0.0026
	Unfavorable	16	6 (37.5)
Budding	Negative	175	13 (7.4)	< 0.0001
	Positive	39	15 (38.5)
Lymphatic	Negative	148	12 (8.1)	0.0012
involvement1	Positive	66	16 (24.2)
Venous involvement	Negative	166	20 (12.1)	NS
	Positive	48	8 (16.7)
Number of LNs	≤ 15	128	16 (12.5)	NS
examined	> 15	86	12 (14.0)
Total		214	28 (13.1)

¹Identified by podoplanin immunostaining. NS: not significant. LN: lymph node; CRC: colorectal cancer.