Adjuvant therapies for colorectal cancer

Table 3 Common adjuvant chemotherapy regimens for colon cancer

Chemotherapy Regimen	Drugs	Route	Dosage	Cycle length and number
Mayo Regimen[58]	5-FU/LV	iv	5-FU, 425 mg/m2 per day d 1-5	28 d
			LV 20 mg/m2 per day d 1-5	6 cycles
Roswell Park [59]	5-FU/LV	iv	5-FU 500 mg/m2 per day weekly × 6	8 wk
			LV 500 mg/m2 per day weekly × 6	4 cycles
Xeloda [24]	Capecitabine	oral	1250 mg/m2	21d
			BD × 14 d	8 cycles
FOLFOX 4 [31]	5-FU/LV	iv	Oxaliplatin 85 mg/m2 d 1	14 d
	Oxaliplatin		LV 200 mg/m2 per d d 1-2	12 cycles
			5-FU 400 mg/m2 per day d 1-2
			5-FU, 600 mg/m2 per d CVI over 22 h, d 1-2
FLOX [32]	5-FU/LV	iv	Oxaliplatin 85 mg/m2 wk 1, 3, 5	8 wk
	Oxaliplatin		LV 500 mg/m2 wk 1-6	3 cycles
			5-FU 500 mg/m2 wk 1-6

CVI: Continuous venous infusion; LV: Leucovorin calcium; iv: intravenous.