Liver expression of steroid hormones and Apolipoprotein D receptors in hepatocellular carcinoma

Table 2 Relationship between AR and ER Immunostaining values and Clinico-Pathological Characteristics

Characteristics	Androgen receptors (AR)		Estrogen receptors (ER)
	n (%)	Score valuesmedian (range)	n (%)	Score valuesmedian (range)
Males	18 (69.2)	4.1 (0-229.5)	12 (46.2)	8.5 (0-65)
Age < 65 yr	15 (71.4)	6.7 (0-52)	10 (47.6)	8.5 (0-65)
Cirrhosis	19 (65.5)	4.2 (0-229.5)	16 (55.2)	8.5 (0-65)
VHC (+)	11 (68.8)	4.2 (0-229.5)	11 (68.8)	8.75 (0-65)
Alcohol etiology	7 (53.8)	3.7 (0-52)	3 (23.1)	0 (0-65)
Uninodular	16 (64)	4.2 (0-229.5)	13 (52)	8.5 (0-65)
Tumor size
< median	13 (61.9)	4 (0-229.5)	12 (57.1)	8.5 (0-65)
≥ median	8 (80)	5.75 (0-16)	4 (40)	8.7 (0-15.75)
Alfa-fetoprotein (ng/mL)
< 20	12 (63.2)	4 (0-229.5)	8 (42.1)	8.5 (0-65)
≥ 20	9 (75)	5.7 (0-31)	8 (66.7)	8.7 (0-16)
Histopathology
HCC-T	20 (71.4)	4.5 (0-229.5)	15 (53.6)	8.5 (0-65)
Non HCC-T	1 (33.3)	1 (0-26.25)	1 (33.3)	0 (0-20.5)
Death
No	11 (84.6)	12 (0-229.5)	6 (46.2)	9 (0-65)
Yes	10 (55.6)	4 (0-28.75)	10 (55.6)	8.5 (0-20.5)
Androgen receptors
Negative	-	-	3 (30)	0 (0-20.5)a
Positive			13 (61.9)	9 (0-65)
Estrogen receptors
Negative	8 (53.3)	3.2 (0-29)	-	-
Positive	13 (81.3)	8.4 (0-229.5)
Progesterone receptors
Negative	0 (0)c	1.7 (0-4.2)a	1 (20)	0 (0-8.5)a
Positive	21 (80.8)	8.4 (0-229.5)	15 (57.7)	9 (0-65)
Apo D
Negative	13 (68.4)	4.2 (0-52)	10 (52.6)	8.5 (0-65)
Positive	8 (66.7)	4.2 (0-229.5)	6 (50)	8.5 (0-65)

^aP < 0.05,

^cP < 0.005. HCC-T: HCC trabecular.