CagA+ H pylori infection is associated with polarization of T helper cell immune responses in gastric carcinogenesis

Figure 2 The relative expression of IFN-γ (A) and IL-4 (B) mRNA in peripheral blood mononuclear cells (PBMCs) and gastric biopsies in patients with CagA+ and CagA- H pylori infection and those without H pylori infection as determined by real time RT-PCR. The relative expression of IFN-γ mRNA decreases from CG to GC, while the relative expression of IL-4 mRNA increases from chronic gastritis (CG) to gastric cancer (GC) in PBMCs and biopsies of CagA+ H pylori infected subjects. However, the magnitudes of relative expression of IFN-γ mRNA and IL-4 mRNA in biopsies are obviously larger than those in PBMCs. There is no difference in the expression of IFN-γ and IL-4 mRNA in PBMCs and local biopsies of subjects with CagA- H pylori infection and of those without H pylori infection.