Protein and non-protein sulfhydryls and disulfides in gastric mucosa and liver after gastrotoxic chemicals and sucralfate: Possible new targets of pharmacologic agents

Table 2 Oxidized glutathione (GSSG) in the mucosa of rat glandular stomach and liver following i.g. administration of gastrotoxic chemicals

	0 min	1 min	3 min	6 min	12 min
Stomach
Ethanol	20.0 ± 3.0	17.0 ± 3.5	26.0 ± 4.0	32.0 ± 5.1	39.0 ± 2.1b
HCl	19.0 ± 6.0	18.0 ± 4.0	18.0 ± 2.8	22.0 ± 4.8	20.0 ± 4.5
NaOH	20.0 ± 2.0	25.0 ± 2.1	26.0 ± 3.7	25.0 ± 4.6	24.0 ± 3.1
NaCl	27.0 ± 1.9	25.0 ± 2.1	35.0 ± 5.7	35.7 ± 6.9	58.0 ± 8.9b
Ammonia	28.1 ± 8.9	34.7 ± 7.1	57.0 ± 9.9	63.0 ± 10.3a	60.0 ± 9.7a
Liver
Ethanol	74.0 ± 13.1	81.4 ± 15.2	64.0 ± 11.3	58.9 ± 10.8	66.6 ± 13.3

The damaging agent, 1 mL of 75% ethanol, 0.6 mol/L HCl, 0.2 mol/L NaOH, 25% NaCl or 1% ammonia-water was given by gavage to fasted S-D rats (n = 4-6), and the animals were killed subsequently at time-points indicated. Data are expressed as mean ± SEM of pmol GSSG in 1 mg wet tissue.

^aP < 0.05,

^bP <0.01, vs corresponding control values (0 min).