A comparative review of HLA associations with hepatitis B and C viral infections across global populations

Table 5 Association of HLA haplotypes with response to HbsAg vaccination across global population

HAPLOTYPE	Effect	Country	Vaccinees	Rs	NRs	References
HLA DR4, 1122 (DRB1*0401-22, 1122)- DR53 (DRB4*0101101, 0102/3)-DQB4 (DQB1*04)	Non-responsiveness	China				[129]
HLA DR14-DR52	Non-responsiveness	Chinese (Taiwan)	Non-responder vaccinees		33	[123]
HLA A1, B8, Bfs, C4AQ0, C4B1, DR3, DQ2 and HLA A1, B8, BfF, C4A6, C4B2, DR3, DQ2	Non-responsiveness	Germany, Poland	ESRD Patients on hemodialysis	34	119	[46]
HLA DRB4*0101-DRB1*0301/DRB3* *0101 DQB1*0202 and DPB1*0201 DRB1*0701/DRB4*0101, DQB1*020*	Non-responsiveness	Belgium	Vaccinees	134	117	[39]
HLA DQB1*0604, DQA1*0102, DRB1*1302 haplotype	Non-responsiveness	Sweden	Healthy vaccinees	69	53	[48]
HLA C4A*Q0, DRB1*0301, DQB1*02	Non-responsiveness	Italy	Neonates	40	26LR, 21SR 10TNR	[41]
HLA C4AQ0, DQB1*02	Non-responsiveness	Italy	Neonates	76	49LR, 43SR 19TNR	[34]
HLA B44-DRB1*0701-DQB1*0202	Non-responsiveness	UK	Vaccinees	117	86	[125]
HLA DRB1*1601, DQB1*0502, DQA1*0102 haplotype	Non-responsiveness	Slovenia	Health care workers	60	36	[126]
HLA B8-DR3	Non-responsiveness	Germany	Healthy adult & infant vaccinees	109	135	[127]
HLA DQB1*0603, DQA1*0102, DR15 and HLA DQB1*0603, DQA1*0103, DRB1*1301 haplotype	Responsiveness	Sweden	Healthy vaccinees	69	53	[48]
HLA DRB1*11, DQB1*0301	Responsiveness	Italy	Neonates	76	49LR, 43SR 19TNR	[34]

ESRD: End stage renal disease. Rs: Responders; NRs: Non responders; LR Low responders; SR: Slow responders, TNR: Total non-responders.