Aquaporin-8 expression is reduced in ileum and induced in colon of patients with ulcerative colitis

Table 4 Selection of differentially expressed genes located in IBD candidate loci

IBDcandidatelocus/Gene	Controlexpressionileum	FCCD	FCUC	Controlexpressioncolon	FCCD	FCUC
Chr. 16q11-12
MMP2	267	1.5	-1.1	220	1.5	3.7
TM4SF11	194	1.3	1.0	151	-2.1	-1.7
SIAH1	208	1.6	1.2	156	3.5	1.3
MT1G	3053	-1.1	1.2	2356	-1.7	-2.0
NETO2	49	-1.6	-1.7	61	2.5	1.4
Chr. 12q13
DGKA	427	-1.5	1.0	342	-2.3	-2.6
MYO1A	1008	1.1	1.1	811	-3.5	-4.3
Chr. 5q32
SPARC	76	2.6	1.5	104	2.0	2.6
TGFBI	236	2.0	1.0	356	1.5	2.5
CAMLG	93	2.5	1.4	91	2.1	1.4
TCF7	357	-2.0	-1.2	279	-1.2	-1.6
SLC35A4	535	-1.5	-1.5	638	-2.3	-1.5
SEC24A	221	2.3	1.1	211	1.7	1.1
SLC26A2	302	2.3	-2.5	388	6.5	-7.5
EGR1	256	2.3	1.1	180	17.1	3.0
PACAP	150	-2.8	-1.7	138	-1.6	2.0
Chr. 19p13
AES	222	-2.1	-1,1	257	-2.5	-2.3
MAP2K2	420	-2.0	-1,1	627	-2.1	-5.7
Chr. 1p36
CDC42	1428	1.1	-1.2	1429	2.0	-1.9
MFN2	304	-1,1	1.0	367	-3.0	-2.5
C1QA	336	1.1	1.1	373	-1.6	-2.5
Chr. 16p12
MIR16	201	-1.7	-1.1	277	-3.0	-1.2
AQP8	575	-8.6	-9.8	438	4.3	3.0
MT1G	3053	-1.1	1.2	2356	-1.7	-2.0
LITAF	500	-1.2	-1.2	670	1.9	2.1
PRKCB1	157	-2.0	1.4	95	1.1	-1.2
USP7	184	1.6	-1.3	192	2.0	-1.1
Chr. 7q11
WBSCR22	172	-1.7	-1.1	207	-1.9	-2.3
POR	213	-2.1	1.0	172	-2.3	-4.9
SEMA3C	79	1.1	1.0	70	2.3	1.9
CLDN3	386	-1.4	-1.2	618	-2.6	-6.5
WBSCR20A	323	-1.6	1.0	281	-2.0	-1.7
TMPIT	928	1.1	1.1	893	-2.3	-2.3
CLDN4	150	1.1	1.0	232	-1.4	-2.3
CD36	153	2.8	1.3	127	2.3	1.1
HSPB1	376	-3.2	-2.3	493	-1.9	-1.5
Chr. 4q25
ELOVL6	112	1.2	-1.6	332	2.1	1.6
ENPEP	578	1.7	1.6	533	1.1	-11.3
T2BP	322	1.2	1.1	224	2.8	1.4
SYNPO2	242	2.3	1.3	160	2.5	1.1
SEC24B	105	2.0	1.6	161	1.6	1.1
Chr. 3p21
ACY1	744	1.1	1.2	485	-2.1	-1.5
Chr. 3q27
AP2M1	417	-1.6	1.0	503	-2.3	-3.5
TNIK	143	2.1	1.1	135	1.4	1.0
PRKCI	68	2.1	1.2	104	2.0	1.1
SI	1313	1.3	1.1	963	1.4	-2.0
EIF4G1	292	-2.5	-1.6	319	-3.7	-6.1
KLHL6	323	-3.2	1.0	110	1.1	1.7
FXR1	137	1.9	1.2	105	2.1	2.0
Chr. 10q22
MYST4	73	2.0	1.4	75	2.0	1.5
RAI17	363	1.6	1.0	250	1.7	2.1

Selection of known genes in IBD candidate loci, which show a two fold change at least in one comparison. CD or UC samples are referred to control specimens. The control expression values are given for the terminal ileum and the colon. At least two fold changes are indicated by bold numbers.