Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: A review and report of personal experience

doi:10.3748/wjg.v12.i9.1336

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Review

World J Gastroenterol. Mar 7, 2006; 12(9): 1336-1345
Published online Mar 7, 2006. doi: 10.3748/wjg.v12.i9.1336

Table 1 Selective COX-2 inhibitors (coxibs) and chemoprevention in gastrointestinal tract tumors

Generic name	Brand name	PhCo^b	Esophagus				Stomach			Colorectum
			Cancer cell line	CIA^c	reflux-induced animal	Human (BE^d)	Cancer cell line	CIA^c	MIA^e	Cancer cell line	CIA^c	MIA^e	Human (FAP^f)
Tricyclic
Celecoxib	Celebrex	Pfizer			(23)			(46,47)	(75)	(76,77)	(81,82)	(54)	(56)
MF-tricyclic	EC^a	Merck			(21)							(53,87)
Rofecoxib	Vioxx	Merck				(24)						(55)
Tilmacoxib	Japan Tobacco			(20)						(78)		(88,89)
Valdecoxib Bextra	Pfizer
EtoricoxibArcoxia	Merck
Methanesulphonamide
NS-398	EC^a	Taisho	(18,19,70,71)				(44,45,72)		(49)	(72)	(83)
Nimesulide	Mesulid	Helsinn					(73)	(48)			(84)	(90)
Flosulide			Schering	(70)
Others
Nabumetone	Relafen	Glaxo Smith Kline									(85)	(91)
Meloxicam	Mobic	Boehringer Ingelheim								(79,80)	(86)
Etodolac	Lodine	Wyeth					(74)			(74)
Lumiracoxib	Prexige	Novartis

ECa, experimental compound; PhCob, Pharmaceutical company; CIAc, carcinogen-induced animal; BEd, Barrett's esophagus; MIAe, mutation-induced animal; FAPf, familial adenomatous polyposis; Numbers in parentheses show reference numbers

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Citation: Fujimura T, Ohta T, Oyama K, Miyashita T, Miwa K. Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: A review and report of personal experience. World J Gastroenterol 2006; 12(9): 1336-1345
URL: https://www.wjgnet.com/1007-9327/full/v12/i9/1336.htm
DOI: https://dx.doi.org/10.3748/wjg.v12.i9.1336

Fujimura T, Ohta T, Oyama K, Miyashita T, Miwa K. Role of cyclooxygenase-2 in the carcinogenesis of gastrointestinal tract cancers: A review and report of personal experience. World J Gastroenterol 2006; 12(9): 1336-1345 [PMID: 16552798 DOI: 10.3748/wjg.v12.i9.1336]

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