Differences in oxidative stress dependence between gastric adenocarcinoma subtypes

Figure 1 Immunohistochemical staining in human gastric adenocarcinoma and precancerous mucosa. A: Intense cytoplasmic immunostaining of iNOS in tumor cells of tubular infiltrative carcinoma (TC), well differentiated; B: Intense cytoplasmic immunostaining of NTYR in tumor cells of TC, moderately differentiated; C: Intense nuclear immunostaining of 8-OH-dG in tumor cells of TC, well differentiated, note the reactivity of the lymphoid follicle (upper left); D: Intense nuclear immunostaining of 8-OH-dG in tumor cells of diffuse carcinoma, note the weak reactivity of some cells of a normal crypt (right); E: Intense nuclear immunostaining of 8-OH-dG in high-grade dysplastic epithelium, note the weak reactivity of a normal crypt (right); and F: Intense cytoplasmic immunostaining of NTYR in low-grade dysplastic epithelium, note the absence of reactivity of a normal crypt (right).