Involvement of mitochondrial Na+–Ca2+ exchange in intestinal pacemaking activity

Figure 1 The effect of clonazepam on the pacemaking activity of ICCs. Clonazepam was applied to examine its effect on the pacemaking activity of ICCs. A: Under a voltage clamp at a holding potential of –60 mV, 50 µmol/L clonazepam inhibited the pacemaking currents of ICCs (n = 4). B: Clonazepam from 20 to 60 µmol/L effectively inhibited Ca²⁺ efflux from mitochondria in the pacemaking activity of ICCs. The IC₅₀ of clonazepam was 37.1 µmol/L.