Antitumor activity of an hTERT promoter-regulated tumor-selective oncolytic adenovirus in human hepatocellular carcinoma

Figure 1 Relationship between telomerase activity of the cell lines and replicative capability of SG300. By telomeric repeat amplification protocol (TRAP) and ELISA assay (A), every cancer cell line was positive for telomerase activity, but the normal fibroblast cell lines were not, whereas the hepatocellular line L02 showed weak telomerase activity. By TCID50 method (B), SG300 replicated selectively in cancer cells but rarely in normal cells (P = 0.0453). The replicative capability of SG300 was coincident with the telomerase activity in various cell lines.