Non-invasive diagnosis of gastric mucosal atrophy in an asymptomatic population with high prevalence of gastric cancer

Table 2 Diagnostic performance of serology (pepsinogen and 17-gastrin) to diagnose gastric atrophy

	Cut-off level	Sensitivity% (95% CI)	Specificity% (95% CI)	LR5+	LR-	Youden’s J index
PG-1 (µg/L)3	< 251	44 (12-77)	95 (87-100)	8.8	0.59	0.40 ± 0.17
	≤ 61.52	78 (40-97)	91 (71-99)	8.6	0.24	0.69 ± 0.15
PG-1/PG-23	< 2.51	56 (21-86)	100 (84-100)	∞	0.44	0.56 ± 0.17
	≤ 2.22
17-gastrin (pmol/L)	< 214	30 (16-58)	86 (70-100)	2.1	0.81	0.16 ± 0.16
	≤ 7.524	90 (56-98)	52 (30-74)	1.89	0.19	0.42 ± 0.14
	> 13.323	67 (30-92)	96 (77-99)	14.7	0.35	0.62 ± 0.16

¹Suggested by the manufacturer;

²Determined by ROC curves;

³To detect corpus-predominant atrophic gastritis;

⁴To detect antrum-predominant atrophic gastritis;

⁵ LR = likelihood ratio.