Precore/basal core promoter mutants and hepatitis B viral DNA levels as predictors for liver deaths and hepatocellular carcinoma

Table 5 Univariate analysis of factors associated with non-HCC related liver deaths

Factor	Alive	Expired	P
n	326	43	-
Age (yr) (mean ± SD)	45.5 ± 14.7	57.2 ± 12.2	< 0.0001
Male/Female	213/113	41/2	< 0.0001
Asian/Non-Asian	264/62	24/19	0.0005
Cirrhosis			< 0.0001
Yes	77/139	38/139
No1	257/261	4/261
Baseline HBV-DNA level (mean ± SD)	6.0 ± 2.38 Log10 copies/mL	6.92 ± 1.96 Log10 copies/mL	0.02
BCP 1762/1764 mutant			0.07
Yes	86	20
No	132	16
PC 1896 mutant			0.78
Yes	86	12
No	223	30
Genotype			0.43
A	46	8
B	76	8
C	126	19
HBeAg			0.17
+	159	26
−	163	17

¹Four other patients without cirrhosis died of non-liver related deaths.