Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis

Figure 3 Marker genes in hepatic stellate cells (HSC). Expression profiles of the whole liver, of isolated HSCs during fibrogenesis, and of in vitro cultured isolated HSCs were obtained using a rat Genome U34A Array (Affymetrix). Marker genes for HSCs are listed. Expression intensities are shown for d 0, and expression intensity data for d 4, 7, 14, 21 and 28 are displayed as ratios to the d 0 expression levels for the analysis of whole liver and isolated HSCs. For in vitro cultured HSCs, the d 0 data are similarly shown as expression intensities, and data on d 4 and 7 are shown as ratios to the expression levels on d 0. Italics indicate an “absent” call by the Affymetrix software, and bold text indicates the highest ratio in the chronic phase (d 7, 14, 21 and 28).